Longitudinal plasma interleukin-6 and post-stroke cognitive outcomes: The Stroke-IMPaCT study - PubMed
3 days ago
- #cognitive decline
- #ischemic stroke
- #inflammation
- Plasma IL-6 levels measured within 96 hours of ischemic stroke and at 6-9 and 18-21 months post-stroke.
- A doubling of IL-6 between admission and 6-9 months was associated with cognitive impairment at 18-21 months (OR = 8.16).
- Each one-unit increase in IL-6 was linked to a 1.5-point decrease in memory Z-scores (β = -1.50).
- Smokers showed persistently blunted IL-6 trajectories and downregulated Toll-like receptor signaling.
- Lower socioeconomic status may relate to 6-month IL-6 concentrations via smoking.
- Post-stroke IL-6 trajectories are associated with later cognitive outcomes, suggesting potential therapeutic targets.