Clinical, molecular and microbial characterisation of the eosinophilic endotype of bronchiectasis: data from the EMBARC-BRIDGE study - PubMed
7 days ago
- #bronchiectasis
- #eosinophilic inflammation
- #Pseudomonas aeruginosa
- Study investigates eosinophilic bronchiectasis using sputum analysis from 180 patients.
- Weak associations found between airway eosinophil proteins and bronchiectasis severity, FEV1, and Pseudomonas aeruginosa infection.
- Eosinophilic bronchiectasis linked to higher Pseudomonas aeruginosa infection and Aspergillus sensitisation.
- LC-MS/MS used to detect eosinophilic inflammation in sputum, providing additional insights beyond blood eosinophil counts.
- No significant difference in sputum inflammatory biomarkers or clinical parameters between eosinophilic and non-eosinophilic groups.