USP1 promotes hepatocellular carcinoma progression by modulating mitophagy via stabilizing MCM3 to regulate the Keap1-Nrf2 axis - PubMed
3 days ago
- #Mitophagy
- #Keap1-Nrf2 axis
- #Hepatocellular Carcinoma
- USP1 promotes hepatocellular carcinoma (HCC) progression by stabilizing MCM3 through deubiquitination.
- MCM3 upregulation in HCC suppresses tumor cell apoptosis and enhances mitophagy, aiding cancer progression.
- MCM3 binds to Keap1, disrupting the Keap1-Nrf2 interaction, which activates the Nrf2 signaling pathway to modulate mitophagy.
- Knockdown of MCM3 inhibits tumor growth in vivo, suggesting its role as a key oncoprotein in HCC.
- Targeting MCM3 could be a potential therapeutic strategy for liver cancer due to its influence on mitophagy and tumor progression.