M2-type tumor-associated macrophages promote invasion of canine breast cancer through ADAM9 upregulation - PubMed
5 hours ago
- #tumor-associated macrophages
- #ADAM9
- #canine breast cancer
- ADAM9 is highly expressed in M2-type tumor-associated macrophages (TAMs) across canine and human breast cancer contexts.
- IL-4-induced M2 macrophages upregulate ADAM9, enhancing tumor migration, invasion, ECM degradation, and cytoskeletal remodeling.
- Knockdown of ADAM9 reduces ECM degradation, MMP9 expression, F-actin disruption, and suppresses TAM-mediated spheroid destabilization and collective invasion.
- Cancer stem cell (CSC)-conditioned medium induces ADAM9 expression, indicating its role in CSC-macrophage crosstalk.
- ADAM9 is identified as a key mediator of TAM-driven tumor invasion and a potential therapeutic target in the tumor immune microenvironment.