Dietary restriction in aging and longevity - PubMed
3 days ago
- #aging
- #longevity
- #dietary restriction
- Dietary restriction (DR) has been practiced for millennia for religious and medical purposes.
- Scientific study of DR at cellular and molecular levels has increased over the past three decades.
- DR paradigms are reviewed in the context of aging, focusing on mammalian findings.
- Potential DR mimetics modulate pathways like autophagy, FGF21, AMPK, mTORC1, NAD+ metabolism, SIRTs, and GLP-1R.
- Organismal and cellular adaptations to DR include fasting, hunger, changes in body temperature, and fat loss.
- Negative effects of DR may include increased vulnerability to infections and impaired wound healing.
- Preclinical evidence suggests DR can improve healthspan and delay age-related diseases like cancer, cardiovascular diseases, and neurodegeneration.
- Future opportunities for translation of DR research are discussed, along with inherent challenges.
- Several authors have competing interests, including affiliations with biotech companies and commercialization agreements.