Lactobacillus johnsonii and 3-indolepropionic acid improve the depression-like behaviors via inhibiting neuroinflammation - PubMed
5 hours ago
- #depression
- #gut-brain-axis
- #neuroinflammation
- Lactobacillus johnsonii and 3-indolepropionic acid (IPA) help reduce depression-like behaviors by inhibiting neuroinflammation.
- Study identifies reduced IPA levels in feces, colon, blood, and hippocampus of CSDS mice, linked to depression-like behaviors.
- L. johnsonii and IPA supplementation alleviated depression-like behaviors and modulated inflammatory markers (AhR, NF-κB, NLRP3, IL-6, IL-1β).
- Antidepressant effects of L. johnsonii and IPA were mediated via the AhR pathway and counteracted by AhR antagonist CH223191.
- First study to report reduced IPA levels in both peripheral and central samples of CSDS mice and link to neuroinflammation.