Histone H4K8 lactylation promotes glioblastoma progression by inducing NUPR1-mediated autophagosome‒lysosome fusion - PubMed
6 days ago
- #Autophagy
- #Glioblastoma
- #Lactylation
- Histone H4K8 lactylation (H4K8la) is significantly increased in glioblastoma (GBM) cells and promotes tumor progression.
- Lactate metabolism and lactylation levels influence GBM malignancy, with inhibition reducing tumor growth in vitro and in vivo.
- H4K8la transcriptionally activates NUPR1, an autophagy regulator, enhancing protective autophagy via autophagosome-lysosome fusion.
- Pharmacological inhibition of NUPR1 with ZZW-115 suppresses GBM growth by impairing autophagic flux, showing therapeutic potential.
- The study identifies the H4K8la-NUPR1 axis as a key regulatory pathway in GBM and suggests targeted therapeutic strategies.