Inhibition of GRK2 mitigates cisplatin-induced acute and chronic nephrotoxicity by targeting the NADPH oxidase 4/oxidative stress axis - PubMed
4 hours ago
- #GRK2
- #NOX4
- #cisplatin nephrotoxicity
- GRK2 inhibition reduces cisplatin-induced nephrotoxicity by targeting NOX4 and oxidative stress.
- Grk2 knockout or knockdown decreases NOX4 expression, reducing ROS and oxidative stress in renal tubular epithelial cells (RTECs).
- GRK2 promotes NOX4 phosphorylation and inhibits its ubiquitin-mediated degradation, increasing NOX4 stability and ROS production.
- The GRK2 inhibitor CP-25 protects against cisplatin-induced kidney damage without affecting its anticancer efficacy.
- Targeting GRK2 could be a renoprotective strategy for patients undergoing cisplatin-based cancer therapy.