Cannabidiol-Induced Tumor Cell Death: Molecular Mechanisms and Translational Perspectives in Cancer Therapy - PubMed
2 days ago
- #Molecular Mechanisms
- #Cancer Therapy
- #Cannabidiol
- CBD, a non-psychoactive compound from cannabis, shows promise as an anticancer agent due to its diverse biological effects and safety.
- It induces tumor cell death via mechanisms including oxidative stress, mitochondrial dysfunction, ER stress, calcium imbalance, and modulation of pathways like PI3K/Akt/mTOR.
- CBD triggers various cell death forms such as apoptosis, autophagy, ferroptosis, pyroptosis, and cell cycle arrest, often as a network response.
- Its potential in cancer therapy includes targeting multiple pathways and improving the tumor microenvironment, but challenges like bioavailability and clinical evidence gaps persist.
- Further research is needed to advance CBD-based anticancer treatments, emphasizing its role as a pleiotropic modulator rather than a single-target drug.