Decoding Neuroinflammatory Pathways: The Role of the CXCL12-CXCR4/CXCR7 Axis in ALS-Related Cognitive Impairment - PubMed
5 hours ago
- #Neuroinflammation
- #ALS
- #Cognitive Impairment
- Cognitive impairment (CI) and neuronal deterioration are key features of amyotrophic lateral sclerosis (ALS).
- The CXCL12-CXCR4/CXCR7 axis plays a crucial role in ALS-related cognitive decline and motor neuron degeneration.
- This axis influences neuroinflammation, synaptic remodeling, and neuronal maintenance via pathways like JAK/STAT, PI3K/AKT, and MAPK.
- CXCL12 and CXCR4 are pivotal in initiating inflammatory responses by mediating inflammatory cell chemotaxis.
- Blocking CXCL12-mediated inflammatory cell migration can mitigate inflammation, making CXCR4 antagonists a promising therapeutic strategy.
- Targeting the CXCL12/CXCR4/CXCR7 pathway may offer neuroprotective benefits and reduce cognitive deficits in ALS.
- Further research is needed to fully understand this pathway and develop effective treatments for neurodegenerative disorders.