PIN1 suppresses bladder cancer progression by inducing cellular senescence and activating the interferon response pathway - PubMed
5 hours ago
- #Cellular Senescence
- #Interferon Pathway
- #Bladder Cancer
- PIN1 is identified as a tumor suppressor in bladder cancer (BCa), contrary to its oncogenic role in other cancers.
- Low PIN1 expression in BCa correlates with poor overall and progression-free survival.
- PIN1 upregulation reduces BCa cell proliferation, migration, and invasion while promoting apoptosis and cellular senescence.
- In vivo studies confirm PIN1's role in suppressing tumor growth and inducing senescence.
- PIN1 activates the interferon response pathway, upregulating IFNAR1, IRF7, and IRF9, which are critical for its tumor-suppressive effects.
- Blockade of the interferon pathway partially reverses PIN1-induced growth suppression and senescence, highlighting its role as a downstream mediator.