The role of gut microbes in production of aromatic carboxaldehydes - PubMed
11 hours ago
- #inflammatory bowel disease
- #metabolites
- #gut microbiome
- Gut microbes produce aromatic carboxaldehydes (ArAs) from aromatic amino acids, impacting health.
- Indole-3-carboxaldehyde (I3A) is linked to antitumor activity, intestinal homeostasis, and metabolic syndrome.
- A new mass spectrometry method was developed to quantify ArAs like benzaldehyde (BA), 4-hydroxybenzaldehyde (4HBA), and 4-imidazolecarboxaldehyde (4IA).
- Antibiotic treatment reduced fecal levels of I3A and 4HBA in humans and mice, indicating microbial origin.
- Crohn's disease patients showed lower fecal levels of I3A and 4HBA compared to controls, unlike ulcerative colitis patients.
- Multiple gut commensals were identified as producers of specific ArAs in culture.