Pyroptosis-Inducing Engineered Microparticles for Cancer Immunotherapy - PubMed
5 hours ago
- #cancer immunotherapy
- #microparticles
- #pyroptosis
- Pyroptosis, a form of immunogenic cell death, can remodel the immunosuppressive tumor microenvironment.
- Geldanamycin (GA) interacts with arginine 207 (R207) in caspase-3, inducing high-efficiency pyroptosis.
- High-dose GA promotes pyroptosis and antitumor immunity but has physiological toxicity and induces resistance via immune checkpoints like PD-L1 and CD47.
- Biomimetic dual-targeting microparticles (MPs) functionalized with anti-PD-L1 and anti-SIRPα nanobodies were developed.
- This strategy combines targeted pyroptosis induction with dual immune checkpoint blockade, achieving complete tumor regression and reduced toxicity in murine models.
- The approach presents a promising combinatorial method for lung cancer immunotherapy.