Foxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for effector Treg cell differentiation - PubMed
6 hours ago
- #Foxp3
- #Treg differentiation
- #BATF
- Foxp3 and BATF cooperate to control cis-regulatory programs and gene expression necessary for effector Treg (eTreg) cell differentiation.
- Single-cell chromatin accessibility and transcriptome profiling identified cis-regulatory elements jointly regulated by Foxp3 and BATF in eTreg cells.
- Foxp3 and BATF co-bind at specific sites, synergistically enhancing chromatin accessibility and transcription.
- Foxp3 acts as a context-dependent master regulator, cooperating or counteracting other TFs to orchestrate diverse regulatory programs across Treg states.
- This cooperation shapes the heterogeneous epigenetic and transcriptional landscapes critical for functional Treg differentiation.