Asperosaponin VI ameliorates osteoporosis via skeletal muscle-derived FGF-2-mediated osteoblast differentiation - PubMed
5 hours ago
- #FGF-2 signaling
- #muscle-bone crosstalk
- #osteoporosis treatment
- Asperosaponin VI (AVI) improves bone structure in ovariectomy-induced osteoporosis mouse models by enhancing osteogenesis and inhibiting osteoclast activity.
- AVI induces a shift from fast- to slow-twitch muscle fibers and promotes osteoblast differentiation via paracrine effects from myotubes.
- Mechanistically, AVI binds to and stabilizes the transcription factor EGR-1 in muscle cells, leading to nuclear translocation and secretion of FGF-2.
- FGF-2 activates the Wnt/β-catenin signaling pathway in osteoblasts through FGFR1, ultimately promoting bone formation and alleviating osteoporosis.