The impact of insulin resistance on cognitive impairment and cerebrospinal fluid biomarkers in Alzheimer's disease - PubMed
6 hours ago
- #Alzheimer's disease
- #Insulin resistance
- #Cognitive impairment
- Insulin resistance is a modifiable risk factor for cognitive impairment and Alzheimer's disease (AD).
- The study involved 200 individuals undergoing cognitive evaluation, blood sampling, and CSF collection.
- Insulin resistance was assessed using the Homeostatic Model Assessment for Insulin Resistance (HOMA).
- No significant differences in HOMA were found between AD and non-AD groups.
- Within the AD group, individuals with dementia had higher insulin resistance than those with mild cognitive impairment.
- Insulin resistance was negatively correlated with global cognition across the full sample.
- In the AD group, insulin resistance independently predicted cognitive performance after adjusting for covariates.
- The findings suggest insulin resistance is linked to more severe cognitive impairment in AD, independent of core AD pathology.
- Addressing insulin resistance may offer therapeutic potential for cognitive disorders.