Convergence of external and internal stressors on a stress-responsive enhancer of the Sonic hedgehog gene to induce hair disorders - PubMed
6 hours ago
- #enhancer regulation
- #Egr1-Shh axis
- #hair follicle stress
- Long-range enhancer of Sonic hedgehog (Shh) gene identified as a hair stress-responsive enhancer (HSRE).
- HSRE and transcription factor Egr1 mediate hair growth arrest and regeneration defects under stress conditions.
- Stress conditions include chemotherapy-induced hair loss, noise-induced dystrophy, and aging/obesity-related delays.
- Under stress, Egr1 suppresses Shh expression, leading to hair disorders, but suppression is absent if HSRE is missing.
- Chemical agents SR11302 and T-5224 that suppress Egr1 rescue hair disorders from various stressors.
- Egr1-Shh axis integrates stress signals to induce hair disorders via Shh suppression, offering therapeutic strategy.
- Research provides paradigm for how stress perturbs organ growth/regeneration by regulating key morphogenetic factors.