Clinical Associations of Cerebrospinal Fluid TMEM106B in Familial and Sporadic Frontotemporal Dementia - PubMed
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- #Cerebrospinal Fluid Biomarkers
- #TMEM106B
- #Frontotemporal Dementia
- Lower CSF TMEM106B levels were associated with more severe disease, lower frontotemporal brain volumes, and faster clinical progression in both discovery and validation cohorts.
- TMEM106B levels were influenced by TMEM106B rs1990622 genotype, with protective G/G genotype linked to lower levels compared to risk A/A genotype.
- CSF TMEM106B levels did not differentiate between FTLD subtypes or between FTLD and Alzheimer's disease.
- Associations with disease severity were independent of neurofilament light chain, suggesting TMEM106B provides distinct clinical information.