AARS1-mediated lactylation of STAT1 drives immune evasion - PubMed
4 hours ago
- #STAT1
- #immune evasion
- #AARS1
- Lactate accumulates in tumor cells due to the Warburg effect, leading to lactylation of STAT1 K193.
- AARS1-mediated lactylation of STAT1 K193 inhibits IFN-γ signaling, reducing chemokine expression (CXCL9, CXCL10, CXCL11) and promoting immune evasion.
- A cell-penetrating peptide, K193-pe, competitively inhibits STAT1 K193 lactylation, restoring tumor sensitivity to IFN-γ and enhancing CD8+ T cell recruitment.
- Targeted inhibition of STAT1 K193 lactylation combined with immunotherapy may improve treatment efficacy.