CBP/p300 is critical for the expansion and maintenance of functional pancreatic α cell mass - PubMed
8 hours ago
- #CBP/p300
- #amino acid sensing
- #pancreatic α cells
- CBP/p300 is essential for maintaining and expanding functional pancreatic α cell mass.
- Knockout of CBP/p300 in mice results in hypoglucagonemia, hyperaminoacidemia, and reduced α cell proliferation and function.
- CBP/p300 deficiency impairs mTORC1 signaling and blocks glucagon receptor antibody-induced α cell proliferation.
- Single-cell RNA sequencing shows increased autophagy-related genes and decreased α cell identity genes and amino acid transporters like Slc7a2.
- Slc7a2 downregulation disrupts arginine-stimulated mTORC1 signaling, suppressing α cell proliferation and promoting autophagy.