Aging-caused the changes of the gut microbiota drive intestinal barrier dysfunction and increase sepsis susceptibility - PubMed
a day ago
- #aging
- #sepsis
- #gut-microbiota
- Aging-related changes in gut microbiota increase susceptibility to sepsis.
- Increased abundance of Klebsiella aerogenes (K. aero) in aged hosts leads to higher histamine (HA) production.
- Histamine exacerbates intestinal barrier dysfunction by inhibiting Nlrp6 expression and impairing autophagy.
- K. aero strains with a histidine decarboxylase gene variant are major HA producers.
- Modulating HA levels or overexpressing Nlrp6 reduces inflammation in septic mice.
- Targeting the HA-Nlrp6-LC3 axis could be a novel therapeutic approach for sepsis in aging populations.