The exposome of brain aging across 34 countries - PubMed
21 hours ago
- #global health
- #brain aging
- #exposome
- Study examines the exposome's impact on brain aging across 34 countries using multimodal brain age measures.
- Aggregated exposome models explained significantly more variance in brain aging than individual exposures.
- Physical exposome factors are primarily linked to accelerated structural brain aging in limbic, subcortical, and cerebellar regions.
- Social exposome factors are more strongly associated with accelerated functional brain aging in frontotemporal and limbic networks.
- Exposome burden increased the risk of accelerated brain aging by 3.3 to 9.1-fold, exceeding the effects of clinical diagnoses.
- Findings were validated out-of-sample and remained consistent across clinical subgroups and after controlling for multiple confounders.
- Highlights the need to address physical, social, and political inequities to mitigate accelerated brain aging.