Cryo-EM structures of heteromeric Kir4.1/5.1 channel suggest mechanisms of inward rectification and channel blockage - PubMed
4 hours ago
- #ion channel structure
- #potassium channel
- #cryo-EM
- Cryo-EM structures reveal heteromeric Kir4.1/5.1 channel in a 2:2 opposite subunit arrangement.
- Structures show polyamines and blockers bind in a membrane-parallel orientation at the upper transmembrane cavity, suggesting an inner-ring blockage mechanism.
- The study provides insights into inward rectification, channel inhibition, and Kir channel pharmacology through structural, electrophysiological, and simulation data.