TRPC6 Governs Brown Adipose Thermogenesis via a BMPR2-p38 MAPK Signaling Axis - PubMed
5 hours ago
- #brown adipose tissue
- #obesity
- #thermogenesis
- TRPC6 is identified as a crucial regulator of brown adipose tissue (BAT) thermogenesis.
- BAT-specific Trpc6 knockout mice show BAT whitening, mitochondrial dysfunction, and impaired cold tolerance.
- Trpc6 knockout mice on a high-fat diet develop obesity, hepatic steatosis, and insulin resistance due to reduced energy expenditure.
- TRPC6 deficiency leads to suppressed mitochondrial biogenesis and thermogenesis.
- TRPC6 interacts with BMPR2 to activate p38 MAPK signaling, driving thermogenic gene expression.
- Disruption of the TRPC6-BMPR2-p38 MAPK axis is linked to obesity and metabolic dysfunction, suggesting a therapeutic target.