ALG1-mediated PDL1 glycosylation drives macrophage m2 polarization to promote bladder cancer progression - PubMed
4 hours ago
- #bladder cancer
- #immunosuppression
- #ALG1 glycosylation
- ALG1 is an enzyme involved in N-glycosylation and plays a key role in bladder cancer progression by modifying PDL1.
- ALG1 glycosylates PDL1, stabilizing it and increasing its expression on the cell surface, which enhances PD1/PDL1 signaling.
- This glycosylation-driven PDL1 stability promotes M2 polarization of tumor-associated macrophages, creating an immunosuppressive tumor microenvironment.
- Inhibition of ALG1 reverses PDL1-mediated immunosuppression and restores sensitivity to anti-PD1 therapy in bladder cancer.
- Targeting ALG1-mediated glycosylation may be a therapeutic strategy to improve immunotherapy outcomes in bladder cancer patients.