Bioinspired IgM-Mimetic Polyvalent Aptamer-Albumin Nanoplatform for Targeted Intravesical Therapy of Bladder Cancer - PubMed
3 hours ago
- #bladder-cancer
- #drug-delivery
- #nanomedicine
- Development of a biomimetic tandem Y-shaped Sgc8 aptamer-albumin delivery system (TYS-HSA) inspired by IgM's multivalent binding.
- TYS-HSA features high ligand valency (~240 aptamers per nanoparticle) for cooperative multivalent recognition and stable target binding.
- Enhanced target binding, prolonged cellular retention, and potent antitumor efficacy demonstrated in an orthotopic bladder cancer model.
- Maintains strong hydrophobic drug-loading capacity (e.g., paclitaxel) with broad drug compatibility and physiological stability.
- Offers a generalizable strategy for targeted albumin-based nanomedicine design in intravesical bladder cancer therapy.