Shenqi Tangluo Pill demonstrates protective impacts on kidney damage in mice with type 2 diabetes through modulation of intestinal flora and the microbial metabolic product Trimethylamine N-oxide (TMA
5 hours ago
- #Gut Microbiota
- #Diabetic Nephropathy
- #Traditional Chinese Medicine
- Shenqi Tangluo Pill (SQTLW) shows protective effects on kidney damage in mice with type 2 diabetes.
- SQTLW modulates intestinal flora and the microbial metabolite Trimethylamine N-oxide (TMAO).
- The study used diabetic db/db mice with an 8-week SQTLW intervention, assessing blood glucose, kidney function, and gut microbiota.
- SQTLW altered bacterial genera like Muribaculaceae and Lachnospiraceae, preserved intestinal barrier, and regulated TMAO-related metabolites.
- SQTLW downregulated renal NLRP3 and Smad2/3 expression, reducing fibrosis-related injury.
- Depletion of gut microbiota with broad-spectrum antibiotics partially attenuated SQTLW's renoprotective effects.
- SQTLW's kidney protection may involve gut microbiota modulation, intestinal barrier preservation, and TMAO pathway regulation.