Dual-crosslinked polysaccharide microspheres via glycated collagen and sodium alginate/chitosan for intestine targeted delivery of curcumin in ulcerative colitis treatment - PubMed
6 hours ago
- #polysaccharide microspheres
- #targeted drug delivery
- #ulcerative colitis
- Dual-crosslinked polysaccharide microspheres were developed for intestine-targeted delivery of curcumin in ulcerative colitis (UC) treatment.
- The microspheres combine glycated collagen (ADCXy) with sodium alginate (SA) and chitosan (CS) to form a multifunctional hydrogel system (ADCXy-Cur-SA-CS).
- ADCXy-Cur-SA-CS demonstrated enhanced cellular antioxidant and anti-inflammatory activity compared to non-glycated versions.
- The system maintained stability in simulated gastric conditions and enabled controlled curcumin release in colonic pH environments.
- In vivo, ADCXy-Cur-SA-CS alleviated UC through antioxidant, anti-inflammatory, mucosal barrier repair, and gut microbiota regulation.
- The study provides a foundation for multifunctional polysaccharide-based hydrogel delivery systems.