Caspase-4 transgenic mice exhibit cytoplasmic TDP-43 accumulation and age-dependent neuropathology - PubMed
2 hours ago
- #TDP-43
- #mouse model
- #neurodegeneration
- Caspase-4 transgenic mice show cytoplasmic TDP-43 accumulation and age-dependent neuropathology.
- These mice mimic cytoplasmic mislocalization of endogenous TDP-43 and motor dysfunction, resembling sporadic ALS.
- CASP4 inhibition via antisense oligonucleotide reduces TDP-43 pathology and neurotoxicity in the model.
- The model aids in studying endogenous TDP-43-mediated pathogenesis and therapeutics.