Core principles of autophagy initiation mechanisms - PubMed
10 hours ago
- #cellular homeostasis
- #autophagy
- #degradation mechanisms
- Autophagy is a conserved intracellular degradation system crucial for cellular homeostasis and adaptation to environmental or metabolic changes.
- Different types of autophagy are induced by various physiological signals through distinct mechanisms.
- Recent advances highlight mechanisms for bulk autophagy during nutrient/energy deprivation and selective autophagy for specific cellular components.
- Shared principles include phase-separation-mediated assembly/activation of factors and coordination between cargo recognition and membrane biogenesis.
- Diverse mechanisms converge on core principles to ensure context-specific autophagy initiation.