GLP-1 receptor agonists and sexual function in women and men: a narrative review of emerging evidence and the need for further research - PubMed
6 hours ago
- #GLP-1 receptor agonists
- #sexual function
- #libido
- GLP-1 receptor agonists (GLP-1 RAs) may influence reward-related and sexual behaviors.
- Animal studies show GLP-1 RAs suppress sexual interaction behaviors in specific brain regions, reducing sexual motivation and performance.
- Human evidence is mixed, with reports of erectile dysfunction and decreased libido, but no significant associations in pharmacovigilance analyses.
- A social media analysis found variable effects on libido, from enhancement due to weight loss to decreased desire.
- A clinical trial in healthy men found no effect of dulaglutide on sexual desire or reproductive function.
- Recent case reports suggest possible female sexual side effects.
- Preclinical evidence supports inhibitory effects on sexual motivation, while human data shows heterogeneous outcomes influenced by various factors.
- Further research is needed to understand the divergence between preclinical and clinical findings.