Increased Expression of Connexin 43 Promotes Wnt/β-Catenin Signaling and the Progression of Temporomandibular Joint Osteoarthritis - PubMed
5 hours ago
- #TMJOA
- #Wnt/β-catenin signaling
- #Connexin 43
- Increased expression of Connexin 43 (Cx43) promotes Wnt/β-catenin signaling in temporomandibular joint osteoarthritis (TMJOA).
- TMJOA progression involves oxidative stress (OS) and abnormal occlusion, with significant activation of the Wnt/β-catenin pathway.
- Cx43 interacts with β-catenin, confirmed by coimmunoprecipitation, suggesting a regulatory role in TMJOA.
- Inhibition of Cx43 with Gap26 reduces Wnt/β-catenin signaling and mitigates degenerative changes in TMJOA models.
- Targeting the Cx43-Wnt/β-catenin axis may offer a therapeutic strategy for TMJOA treatment.