Neuregulin-1 facilitates myelin regeneration through microglia-mediated mechanisms in a mouse model of chronic demyelination - PubMed
3 hours ago
- #microglia
- #neuregulin-1
- #myelin regeneration
- Neuregulin-1 positively correlates with impaired oligodendrocyte remyelination in a mouse model of chronic demyelination, suggesting a key role in myelin repair.
- Restoring neuregulin-1 therapeutically promotes myelin regeneration by enhancing microglia-dependent mechanisms, including myelin debris clearance and cholesterol processing.
- In chronic demyelinated lesions, microglia lose reparative function and become dysfunctional with lipid droplet accumulation; neuregulin-1 signaling supports microglia integrity and function.
- Neuregulin-1 facilitates cholesterol recycling, biosynthesis, and efflux in microglia, addressing lipid metabolism issues crucial for remyelination in progressive multiple sclerosis.
- The findings highlight neuregulin-1 as a promising endogenous target to restore microglia-mediated repair in progressive MS, where effective treatments are currently lacking.