Small-molecule binding and sensing with a designed protein family - PubMed
5 hours ago
- #protein design
- #deep learning
- #small-molecule sensing
- Combined deep learning and physics-based methods to create a protein family with diverse, designable pockets for small-molecule binding.
- Computationally designed binders for six small-molecule targets achieved nanomolar to low micromolar affinities with atomic-level accuracy.
- Used a designed cortisol binder to develop a chemically induced dimerization (CID) system for a cortisol biosensor.
- Demonstrates the potential of the NTF2 fold and deep learning in designing sensors for analytical, environmental, and biomedical applications.
- Authors have filed provisional patent applications related to the designed protein sequences, indicating commercial interest.