Beyond metabolic dormancy: metabolic rewiring in bacterial persistence - PubMed
5 hours ago
- #Bacterial Persisters
- #Metabolic Rewiring
- #Antibiotic Tolerance
- Bacterial persister cells exhibit transient antibiotic tolerance and are important in chronic and recurring infections.
- Persister metabolism is shaped by genetics, environmental cues, and intrinsic cellular variability, leading to diversity among cells.
- Persisters are not uniformly metabolically dormant but represent a range of metabolic states, challenging classic hallmarks like biphasic killing curves.
- The review focuses on the unique metabolic rewiring in persisters, which depends on both internal and external factors.