The cellular orchestra of CAR T success - PubMed
7 days ago
- #CAR T cell therapy
- #multiple myeloma
- #BCMA-directed therapy
- Rade et al. report a longitudinal single-cell atlas of multiple myeloma patients receiving BCMA-directed CAR T cell therapy.
- Identified features linked to long-term responses include CD4+ T cell-driven cytotoxicity, memory-biased T cell states, reduced exhaustion, and microenvironment effects.
- The study involves two types of CAR T cell therapies: ide-cel and cilta-cel.
- Conflict of interest disclosures include consulting, advisory roles, or research funding from multiple pharmaceutical companies.