Mechanical regulation of cuboidal-to-squamous epithelial transition in the Drosophila developing wing - PubMed
8 hours ago
- #epithelial morphogenesis
- #tissue mechanics
- #Drosophila development
- Tissue-extrinsic mechanical stress from the wing disc bending induces a cuboidal-to-squamous transition in central peripodial epithelium cells.
- A rigid basement membrane protects peripheral margin cells from bending stress, leading to a cuboidal-to-columnar transition instead.
- Selective shearing of central cells, mediated by the apical extracellular matrix protein Dumpy, amplifies these shape transitions.
- The interplay between basement membrane properties and inter-tissue coupling is crucial for generating stress patterns and cell deformations during organ growth.