Ironing out COPD: ferroptosis-driven immune dysregulation, metabolic rewiring, and precision therapeutic opportunities - PubMed
6 hours ago
- #COPD
- #precision medicine
- #ferroptosis
- COPD is a global health crisis driven by oxidative stress and immune dysregulation.
- Ferroptosis, an iron-dependent cell death, is a key mediator in COPD pathogenesis.
- Cigarette smoke induces mitochondrial fission, exacerbating ferroptosis in airway epithelial cells.
- Nrf2 signaling's complex role in COPD: suppressed globally but dysfunction in macrophages may promote ferroptosis.
- Plasma malondialdehyde (MDA) serves as a biomarker for oxidative stress severity in COPD.
- Targeted therapeutic strategies like inhaled exosomes with liproxstatin-1 show promise in inhibiting pulmonary ferroptosis.
- The review highlights the ferroptosis-immune axis for precision medicine in COPD.