Neuroimmunometabolic co-evolution in the tumor micro- and macroenvironment - PubMed
5 hours ago
- #cancer neuroscience
- #tumor microenvironment
- #neuroimmune interactions
- The nervous system integrates immune, endocrine, and circulatory systems to influence tumor progression and treatment resistance.
- Neuroimmunometabolic co-evolution occurs in both the tumor microenvironment (TME) and tumor macroenvironment (TMaE).
- The peripheral nervous system (PNS) regulates metabolic processes and immune cell functions within the TME.
- Cancer cells exploit brain-body interactions to reprogram systemic metabolism and immune responses in the TMaE.
- The PNS facilitates long-range communication between tumors and distant organs.
- Key knowledge gaps and potential neuroimmune/neurometabolic therapies are discussed.