Metabolic Dysfunction-Associated Steatotic Liver Disease in Pregnancy: A Review - PubMed
3 days ago
- #pregnancy complications
- #liver disease
- #MASLD
- Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is characterized by fatty liver deposits without alcohol misuse.
- MASLD is linked to metabolic comorbidities like obesity and insulin resistance, and pregnancy complications such as gestational diabetes and hypertensive disorders.
- The prevalence of MASLD in pregnant individuals is around 14%.
- Obesity and pregnancy physiological changes may synergistically initiate or worsen liver steatosis.
- MASLD is associated with adverse maternal and offspring outcomes, including preterm birth, miscarriage, and metabolic disease in offspring.
- Early detection may warrant diabetes screening and low-dose aspirin due to associations with gestational diabetes and hypertensive disorders.
- Further research is needed for optimal screening, diagnosis, and management of MASLD in pregnancy.