Association between omeprazole and memory impairment: Insights from NHANES data analysis and network pharmacology studies - PubMed
8 hours ago
- #Omeprazole
- #Memory Impairment
- #NHANES
- Post-marketing surveillance suggests a possible link between omeprazole use and cognitive changes, but observational studies have shown conflicting results, indicating a need for systematic investigation.
- This study used NHANES data analysis and network pharmacology to examine omeprazole's association with memory impairment, finding a significant positive link (OR = 3.51) in NHANES and identifying 342 core Alzheimer's disease-related targets.
- Network pharmacology identified top binding targets like UBA52 and EGFR, with enrichment analysis suggesting omeprazole may affect memory through pathways such as carboxylic acid metabolism and membrane transport.
- The research concludes that regular omeprazole consumption increases the risk of memory-related cognitive issues, based on population studies and drug safety reports.