Multiple sclerosis and autoimmunity: a reappraisal of the evidence - PubMed
5 hours ago
- #multiple sclerosis
- #autoimmunity
- #neurodegeneration
- Multiple sclerosis (MS) pathogenesis involves immune dysregulation, but definitive self-antigens or antibodies remain unidentified.
- The review questions whether immune activation initiates MS or responds to earlier pathological events, highlighting gaps in current models.
- Reclassification of conditions like MOGAD and NMOSD prompts reevaluation of MS as an autoimmune disease, using criterion-based comparisons.
- Clarifying MS's autoimmune status impacts experimental modeling, biomarker discovery, and therapeutic development beyond conventional frameworks.