Inhaled Corticosteroids Monotherapy in Childhood Asthma: Any Differential Response Rate between Activated and Prodrugs? - PubMed
4 hours ago
- #pediatric asthma
- #asthma control
- #inhaled corticosteroids
- The study compared the real-life success of inhaled corticosteroids (ICS) as prodrugs (inactive at delivery) versus activated ICS in preventing poor asthma control and exacerbations in children with asthma.
- A retrospective cohort study involved 213 children aged 1-17 years initiating new maintenance ICS monotherapy at low or medium doses, including both incident users and switchers.
- Most participants were prescribed activated ICS (primarily fluticasone propionate), while prodrug ICS was exclusively ciclesonide, with 61% using low-dose ICS.
- The odds of unsatisfactory asthma control were significantly higher in the prodrug group compared to the activated ICS group, with an adjusted odds ratio of 2.35.
- No significant difference was found between the groups in the occurrence of severe exacerbations, with an adjusted odds ratio of 0.92.