Oral microbiome and Frailty: Insights from NHANES 2009-2012 and Mendelian Randomization Analysis - PubMed
7 hours ago
- #oral microbiome
- #healthy aging
- #frailty
- Frailty is linked to higher risks of disability, hospitalization, and mortality.
- The study explores the connection between oral microbiome diversity and frailty using NHANES 2009-2012 data and Mendelian randomization analysis.
- Lower α-diversity in the oral microbiome was associated with higher frailty scores.
- β-diversity in the oral microbiome differed significantly by frailty status.
- Specific oral bacteria like Campylobacter_A and Saccharimonadaceae showed protective effects against frailty, while others like Gemella increased frailty risk.
- The findings suggest the oral microbiome could be a modifiable target for promoting healthy aging.