Indirect treatment comparison of DVRd plus DR maintenance (PERSEUS study) versus DVTd or VTd with or without lenalidomide maintenance in transplant-eligible patients with previously untreated multiple
5 days ago
- #Indirect Treatment Comparison
- #Maintenance Therapy
- #Multiple Myeloma
- Comparison of DVRd plus DR maintenance versus DVTd or VTd with/without lenalidomide maintenance in transplant-eligible newly diagnosed multiple myeloma (TE NDMM) patients.
- DVRd + DR showed superior progression-free survival compared to DVTd + Obs, VTd + Obs, DVTd + R, and VTd + R.
- Study limitations include unanchored indirect treatment comparison and potential residual confounding despite adjustments.
- Conclusions suggest DVRd followed by DR maintenance offers superior survival outcomes compared to current standards of care in TE NDMM patients.