Cytoplasmic Fidgetin Induces Noncanonical Activation of β-catenin to Support Cancer Progression - PubMed
6 hours ago
- #Beta-catenin
- #Fidgetin
- #Cancer Progression
- Cytoplasmic Fidgetin (FIGN) is associated with poor prognosis in breast carcinoma, hepatocellular carcinoma, and lung adenocarcinoma.
- FIGN interacts with MYH2 and HNRNPA2B1; MYH2 regulates FIGN's nucleocytoplasmic distribution, while cytoplasmic FIGN stabilizes β-catenin mRNA via HNRNPA2B1.
- An iRGD-fused peptide blocking the MYH2-FIGN interface can translocate FIGN to the nucleus, suppressing cancer progression.