Endoplasmic reticulum-mitochondria contact sites are signalling hubs connecting nutrient sensing and GLP-1 secretion in L cells of the mouse gut: from physiology to obesity and type 2 diabetes - PubMe
5 days ago
- #GLP-1
- #diabetes
- #mitochondria
- ER-mitochondria contact sites (MAMs) play a key role in nutrient-induced GLP-1 secretion in L cells.
- Glucose and deoxycholic acid (DCA) dynamically increase ER-mitochondria interactions in L cells.
- Disruption of ER-mitochondria communication blocks GLP-1 secretion in response to glucose and DCA.
- Glucose enhances ER-mitochondria calcium exchange, crucial for GLP-1 secretion.
- GLP-1 secretion is impaired in obesity and type 2 diabetes due to altered ER-mitochondria interactions.
- Targeting MAMs could improve glycemic outcomes in metabolic diseases.