Glial Triad in Diabetic Neuropathy: Central Players in Neuropathic Pain Pathogenesis and Disease-Modifying Therapeutic Avenues - PubMed
5 hours ago
- #diabetic-neuropathy
- #glial-cells
- #neuropathic-pain
- Painful diabetic neuropathy (PDN) is a debilitating complication of diabetes with no current disease-modifying therapies.
- The 'glial triad'—microglia, astrocytes, and oligodendrocytes—plays a central role in PDN pathogenesis.
- Key mechanisms include NLRP3 inflammasome activation in microglia, AQP4 polarity disruption in astrocytes, and mTOR-related myelination deficits in oligodendrocytes.
- Potential biomarkers like TSPO, GFAP, and MBP could aid in early diagnosis and patient stratification.
- Promising therapeutic targets include IL-35, β-hydroxybutyrate, and metformin, aiming for disease modification rather than symptomatic relief.