Assembly of helper NLR resistosome clusters upon activation of a coiled-coil NLR - PubMed
14 hours ago
- #cell death
- #plant immunity
- #NLR resistosome
- Plant NLR immune receptors detect pathogen effectors and activate immunity.
- Coiled-coil NLRs (CNLs) form resistosomes as Ca2+-permeable channels in the plasma membrane (PM).
- SUMM2, a CNL, tethers to the PM through N-myristoylation, essential for cell death.
- Active SUMM2 promotes association of EDS1 and PAD4 with helper NLR ADR1-L1.
- SUMM2 induces clustering of ADR1-L1 resistosomes into ring-like assemblies with EDS1-PAD4 complex.
- The EDS1-PAD4-ADR1 module is crucial for SUMM2-activated cell death.
- N-myristoylation-mediated PM targeting of SUMM2 enables higher-order resistosome clusters for cell death initiation.