Decoding the spatiotemporal development of human meninges - PubMed
2 hours ago
- #meningeal development
- #spatial transcriptomics
- #neuro-immunity
- Used single-cell spatiotemporal transcriptomics from 6–23 gestational weeks to study human meninges development.
- Identified asynchronous development of meningeal layers, with pia mater forming first.
- Defined layer-specific fibroblast states expressing barrier, neurotransmitter, synapse, and lipid metabolism genes.
- Characterized spatiotemporal heterogeneity in meningeal immune cells, including a meningeal-specific macrophage population.
- Found pia mater recruits and organizes immune cells via CXCL12-CXCR4 signaling, particularly macrophages in leptomeninges.
- Discovered Trem2+ macrophages regulate development of Cajal-Retzius cells in cerebral cortex.
- Established a spatiotemporal framework for human meningeal development and uncovered neuro-immune interactions.
- Identified potential therapeutic targets based on findings.